The goal of the Behavioral Intervention Development Core (BID Core) is to conduct innovative pilot research aligned with the goals of the NIA Roybal Centers for Translational Research on Aging and with scientific direction provided by the External Advisory Committee (EAC). We will support pilot studies in Stages 0-IV of the NIH Stage Model for behavior change, focusing on Stage IA pilots to modify, adapt, and refine existing interventions and Stage IB feasibility pilots, and will advance to later stages as appropriate. Pilot testing will be concentrated in our thematic focus areas for this funding announcement including Utilizing Behavioral Economic Approaches to Improve Individual Behavior and/or Institutional Processes, Targeting Mechanisms of Behavior Change Common to Multiple Health Behaviors, Leveraging Technology to Ensure Fidelity and/or Scalability, and Promoting Adherence and Maintenance of Long-term Behavior Change. In addition, our pilots will leverage human-centered design to improve the user experience, deploy technology platforms that facilitate testing ideas at scale, and use artificial intelligence (AI)-informed dynamic adaptation to improve the effectiveness of interventions under resource constraints. The primary aim of the BID Core is to support mechanistically-grounded pilot projects with the potential— through rigorous design, refinement, and feasibility testing, followed by efficacy and effectiveness testing—to translate ideas from behavioral economics into practice and to improve health among middle-aged and older Americans with modifiable risk for morbidity and mortality. We will prioritize the mentorship and training of junior faculty and trainees, interaction between investigators at Penn and other universities, and the building of effective collaborations with organizations that can translate research finding into results at scale. In addition to the pilots supported through this proposal, we will continue to utilize other sources of support, including federal and private sources, to advance a broader portfolio of research of high relevance to the Roybal mission. Our BID Core will emphasize pilots that advance us towards success in bridging the efficacy- to-effectiveness gap and solving for scale. We will also leverage the three strategic foci of our proposal: design thinking, digital platforms, and dynamic adaptation. Our strategic foci will inform all funded pilots, and will increase our ability to engage diverse populations, to do so at scale, and to “learn as we go” for rapid and relevant results.