# Howard University Research Center for Minority Health and Health Disparities

> **NIH NIH U54** · HOWARD UNIVERSITY · 2023 · $220,850

## Abstract

There are mounƟng evidence showing children exposed to HIV but uninfected (HEU) during
pregnancy as the pregnant mother is on chronic cART present with higher cardiovascular risk at
birth and beyond. In order to miƟgate these risks, there is an urgent need to understand the
effects of the daily intake of the recommended HIV treatment, combined anƟretroviral therapy
(cART), on the newborn during pregnancy. It is important to isolate the cardiac side effects of
the cART in HEU from any residual maternal viral load effects. Therefore, we will study the
effects the components of the cART given to non-infected pregnant rodent model on the HEU.
Furthermore, an assessment of the breastieeding potenƟal compounding effect will be
performed on breastied rodents. This study is of high relevance to the communiƟes with high
HIV risk and cardiovascular diseases, such as in underserved populaƟon afflicted with health
dispariƟes. Understanding the cause can help future studies to alleviate the symptoms.

## Key facts

- **NIH application ID:** 10874292
- **Project number:** 3U54MD007597-35S2
- **Recipient organization:** HOWARD UNIVERSITY
- **Principal Investigator:** William M. Southerland
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $220,850
- **Award type:** 3
- **Project period:** 1997-09-30 → 2024-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10874292

## Citation

> US National Institutes of Health, RePORTER application 10874292, Howard University Research Center for Minority Health and Health Disparities (3U54MD007597-35S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10874292. Licensed CC0.

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