# MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD): Behavioral Intervention Development Core

> **NIH NIH P30** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $755,018

## Abstract

PROJECT SUMMARY (BEHAVIORAL INTERVENTION DEVELOPMENT CORE):
The mission of the “MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer’s
Disease and Related Dementias” (CONFIDE-ADRD) is the development, optimization, testing and implementation of
dyadic behavioral prevention interventions (DBPIs) across the spectrum of ADRD in both hospital and community settings,
to improve health and prevent negative individual and dyadic health outcomes. The Behavioral Intervention Development
Core (BIDC) will support the CONFIDE-ADRD mission through 3 specific aims: Aim 1: Accelerate translation of DBPIs
across the NIH Stage Model for steadfast implementation; Aim 2: Facilitate a program of dementia DBPI mechanistic pilot
studies using a novel accelerator model for team project management and continuous performance review with feedback
and plan for skill improvement to support pilot funded investigators to conduct rigorous dementia DBPIs with efficient
translation; and Aim 3: Catalyze translation and foster pilot program synergies across MGH/HMS, Roybal Centers and
nationally. We will distribute a national call for applications. Investigators will submit a letter of intent. We will meet with
selected investigators to review aims, explore available resources and expertise, establish a plan for aim completion and
diversity in the sample, and determine a timeline for proposal development and pathway progression including subsequent
funding for the next stage of work. Meetings will be over zoom. This early support will ensure that the applicants fully
understand our conceptual framework including the NIH stage model, definition of dyadic research, and dyadic theoretical
processes, so that they submit competitive, rigorous applications. Pilot awardees will interact with CONFIDE-ADRD
weekly for the funded pilot year(s) so that they: 1) are connected to the broader resources and expertise in DBPIs; 2) receive
directed support to overcome potential barriers; and 3) develop a network of other dementia pilot awardees through MADRC,
RCMAR, NIA dementia palliative R25, and Roybal Centers. We will support Pilot Awardees to submit their subsequent
NIH grant. Per the RFA, each pilot will last between 1-3 years and will be fully powered. We received 32 applications for
our first call for applications and selected 2. The first pilot (social worker-led) will test the preliminary efficacy (NIH 1B)
of Let’s Talk Tech, a dyadic intervention to support conversations about the use of technology in dementia dyads. The second
pilot (psychologist-led) will first culturally adapt SHARE, an evidence-based program to support conversations around care
values and preferences early after dementia diagnoses, for the needs of African American patient-partner dyads, and then
pilot test (NIH 1B) its preliminary efficacy. Activities in this aim will strengthen synergies across MGH/HMS, locally and
nationally thus facilitating greater collective impact of our cor...

## Key facts

- **NIH application ID:** 10874324
- **Project number:** 1P30AG086562-01
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Ana-Maria Vranceanu
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $755,018
- **Award type:** 1
- **Project period:** 2024-08-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10874324

## Citation

> US National Institutes of Health, RePORTER application 10874324, MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD): Behavioral Intervention Development Core (1P30AG086562-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10874324. Licensed CC0.

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