# Stanford MoTrPAC Bioinformatics Center

> **NIH NIH U24** · STANFORD UNIVERSITY · 2023 · $1,995,887

## Abstract

Abstract
Few interventions have been shown to be as beneficial to human health as physical activity, yet we remain
largely ignorant of the mechanisms by which these potent health effects are transduced. The Molecular
Transducers of Physical Activity Consortium examines the response to acute and chronic exercise at
multiple scales and in multiple tissues across thousands of humans and in animal models. MoTrPAC combines
multi-scale phenotyping with molecular multi-omics approaches. Building on our long history of analytical
innovation in high throughput biology and computational innovation, the Stanford MoTrPAC Bioinformatics
Center will provide computational, bioinformatic and analytic expertise to the Consortium. Leveraging
scalability and reproducibility approaches enabled by cloud architecture, we provide a robust platform for the
sharing and analysis of multi-tissue, multi-omic, physiological and sensor based measurement data. Aim 1 is
focused on advancing our cloud-based data warehouse for raw and processed data. We will achieve this by
extending work enabling data access and data processing, advancing data management and scalable search.
Aim 2 implements existing omics pipelines and the development of new pipelines for human multi-omic data.
In addition, we extend analytic approaches for multi-scale, high-throughput data from human and animal
studies. We will expand robust data analysis pipelines and code repositories built with FAIR principles in mind.
In addition, we will continue incorporating data integration and novel visualization approaches. Aim 3 expands
and extends our interactive interface for investigators and the public to interrogate, interact with, explore, and
download MoTrPAC data. In addition, deposition of MoTrPAC data to durable, public repositories and of code
and analysis packages to public collaboratories, together with dissemination activities developed by the BIC on
behalf of the Consortium will extend the utility and utilization of the work of the Consortium to advance the
science of physical activity. With the expertise, experience, infrastructure and tools already in place, the
Stanford MoTrPAC Bioinformatics Center is well-positioned to deliver on the vision of MoTrPAC, from data
collection, processing and analysis to exploration and dissemination.

## Key facts

- **NIH application ID:** 10874842
- **Project number:** 3U24OD026629-06S2
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Euan A Ashley
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,995,887
- **Award type:** 3
- **Project period:** 2016-12-12 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10874842

## Citation

> US National Institutes of Health, RePORTER application 10874842, Stanford MoTrPAC Bioinformatics Center (3U24OD026629-06S2). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10874842. Licensed CC0.

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