Data Science Core Abstract The WV-INBRE Data Science Core (DSC) is a centralized resource that will provide training and education in data science for biomedical researchers and students, access to technical expertise in data science, and access to cyberinfrastructure for network researchers. The DSC will collaborate closely with the WV-INBRE Sequencing, Molecular and Related Technologies (SMART) Core to provide seamless, integrated services in genomics to investigators at the lead and undergraduate institutions in the WV-INBRE network. Genomic services offered by the DSC and SMART Core will include experimental design, library preparation and next-generation sequencing (NGS), and data analysis and interpretation. The two cores will continue to provide whole genome, whole exome, RNA-Seq, microbiome and global chromatin sequencing, and will add as new NGS services single-cell and spatial transcriptomics. The DSC will build expertise in data science in the WV-INBRE network by developing a comprehensive series of online training modules. The training modules will be freely available for self-study and will be used as source material for annual instructor-led training workshops in data science and its applications to biomedical sciences. The training modules will also be used in undergraduate education, forming part of an expanded Summer Bioinformatics Bootcamp for undergraduates in IDeA states in the southeast region, as well as in undergraduate courses which will be developed at West Liberty University as part of a bioinformatics program. The DSC will provide access to cyberinfrastructure both by maintaining a high-performance computing (HPC) cluster at Marshall University, and by providing access to cloud computing resources to network investigators via a membership of the Ohio Supercomputer Center. Our primary aim is to provide services and build expertise in data science and its applications to biomedical sciences. This expertise will empower investigators to bring machine learning, big data, artificial intelligence, and related technologies to their biomedical research, enhancing their ability to gain a deeper understanding of chronic diseases that are prevalent in West Virginia.