Our proposed UIC Midwest Roybal Center for Health Promotion and Translation seeks to accelerate the translation of behavioral research interventions into practical outcomes to improve the functioning (cognitive and physical) and quality of life of older adults at risk of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). Our work recognizes that interventions that target individuals take place in families, neighborhoods, and communities that are impacted by external factors that influence initiation and maintenance of behavior change. Our work is guided by the PRISM Framework to identify behavioral interventions that have the greatest potential for broad public health impact. Our Center will support the design and testing of principle-driven and mechanism-focused, potent and sustainable health promotion interventions that have a strong promise of progressing through the NIH Stage Model. Our renewal Center retains its current focus on designing interventions for older racial/ethnic minority adults and expands our focus to target older adults at risk of AD/ADRD with a focus on behavioral interventions that address cognitive health. This renewal application targets four thematic areas of focus: Develop and test principle driven interventions to increase physical activity (PA) among older adults at risk of ADRD, Design interventions to maintain and/or enhance cognitive function and mobility; harness technology to improve intervention scalability and fidelity; and target mechanisms of behavior change to promote and sustain behavioral and lifestyle change. These foci simultaneously will advance science in these areas and reflects areas of substantial expertise within our Roybal Center. Faculty serving on the Administrative and Behavioral Intervention Development (BID) Cores will constitute the Center’s Executive Committee. These faculty have extensive expertise related to the thematic foci of the center and are committed to assisting to fulfill the mission of the Center. These faculty have experience conducting research across all stages of the Stage Model and will work to transition promising interventions across the Stage Model as quickly as possible. The MPI’s will serve as the Administrative Core co-leads and provide oversight to and work collaboratively with the BID Core co-leads. The BID Core will provide grant funding for up to two trials per year, one solicited from all departments across UIC and other University of Illinois campuses and one solicited externally via a National competition. The overall performance of the Center will be guided by a distinguished External Advisory Committee that includes representatives from diverse academic, provider, funder, consumer, and media stakeholder groups; including health care systems and plans. Collectively our work is expected to substantially advance science in these critically important areas of focus and provide currently unavailable information about the impact of behavioral ...