The overall goal of our Midwest Roybal Center for Health Promotion and Translation is to advance the science, translation, and practice of health promotion programs for older adults at risk of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) in order to improve the functioning (physical and cognitive) and quality of life of this growing segment of our population. To achieve this mission, this renewal Center will sponsor, facilitate and monitor the development and testing of interventions that will advance scientific knowledge in four areas of thematic focus. The areas of research focus are: a) Develop and test principle driven interventions to increase physical activity (PA) among older adults at risk of AD/ADRD; b) Design interventions to maintain and/or enhance cognitive function and mobility; c) Harness technology to promote healthy cognitive aging and to improve the scalability of existing interventions for cognitive health including PA, diet, and stress reduction; d) Target mechanisms of behavior change to promote and sustain behavioral and lifestyle change. We will work with an outstanding External Advisory Committee and talented UIC faculty on our Executive Committee to foster and execute the following Aims: Aim 1. Develop and maintain a strategic vision; ensuring that all relevant Stages of expertise in the NIH Stage Model will be represented within the Center and the ways that experts across the Stage Model will interact; Aim 2. Manage an External Advisory Committee that will include expertise in behavioral intervention development and will oversee Center functioning and assist the Directors in making scientific and administrative decisions including the allocation of funds for intervention studies; Aim 3. Develop a review panel that will identify, review and monitor clinical trials and behavioral interventions in a manner consistent with progression through the NIH Stage Model and overall Center goals; Aim 4. Monitor all clinical trials and describe their results in standardized annual progress reports to NIA; Aim 5. Work with NIA and the Roybal Coordinating Center to develop metrics that can be used to evaluate clinical trials and code key characteristics that can be used to compare them. Aim 6. Coordinate travel to national Roybal Center meetings annually at meeting sites designated by NIA and share key findings with other funded Centers; Aim 7. Encourage/Facilitate the development of networks among researchers, commercial interests, community interests, program design interests, and governmental entities to support translation activities that will expand the reach of our Center’s activities. The achievement of these aims and the conduct of rigorous research in the thematic areas of focus identified are expected to contribute substantially to reduced risk for AD and improved cognitive and physical functioning of older adults in Chicago, the Midwest, nationally and, potentially, internationally.