Behavioral Intervention Development (BID) Core Abstract The overall goal of our Midwest Roybal Center for Health Promotion and Translation is to advance the science, translation, and practice of health promotion programs for older adults at risk of AD/ADRD. The BID Core will enable us to achieve that goal by identifying talented investigators and providing them with mentoring, support, and incentives that will enable them to test impactful interventions. Interventions that we support will be highly feasible for immediate translation and implementation into practice while advancing science in our areas of thematic focus. Our thematic foci for this renewal application include: a. Develop and test principle driven interventions to increase physical activity (PA) among older adults at risk of ADRD; b. Design interventions to maintain and/or enhance cognitive function and mobility; c. Harness technology to promote healthy cognitive aging and to improve the scalability of existing interventions for cognitive health including PA, diet, and stress reduction; d. Target mechanisms of behavior change (MOBC) to promote and sustain behavioral and lifestyle change. To achieve these aims, we will issue annual calls for internal and external investigators to apply to a national competition that will seek to identify the most promising, potent and scalable applications that address these foci and have the potential to advance science in at least one of these areas. We will require that all applications use and identify a MOBC and that the specific aims of each application identify a hypothesized mechanism of action (MOA). Successful applications will be required to have adequate statistical power to achieve interpretable results. The two proposed Year One trials meet these criteria. Dr. Motl's Stage I trial extends his Life Light Physical Activity (LPA) intervention that was tested with persons with Multiple Sclerosis to persons with Parkinson's Disease (PD) who are at high risk for dementia. LPD combines Social Cognitive Theory (SCT) counseling with PA that occurs while performing Activities of Daily Living. Endpoints are step counts, improved cognitive function, and MR imaging. Dr. Aquinaga's Stage II trial builds on her current trial of a combined dance and diet intervention for older Latinos who are at high risk for AD/ADRD. Since evidence indicates a combination of aerobic and strength exercises have the largest impact on cognition, she will test the benefit of adding strength training to her existing intervention. Outcomes are executive function and multiple biomarkers. MOA are changes in Insulin growth factor 1 and homocysteine levels produced by the strength training. Both trials have anticipated pathways to advance through the NIH Stage Model stages.