Project Summary / Abstract: Administrative Core The Roybal Center Administrative Core will provide scientific leadership, organizational management and governance, financial oversight, systems for monitoring progress and compliance, and infrastructure to promote transdisciplinary interaction, collaboration, and synergy among center components. The Administrative Core will manage the Roybal Center's overall mission and annual goals, support the Roybal Center Behavioral Intervention Development (BID) Core, project science, and internal and external communication. To that end, the Administrative Core's function can be summarized into three specific aims. Aim 1. Maintain the Center's strategic vision. The Administrative Core will plan, coordinate, review and manage the Center's activities. These activities will be summarized and communicated by the Administrative Core through the Roybal Center's website. Furthermore, the Administrative Core will manage an External Advisory Committee that oversees the functioning of the Center and assists the PIs in making the scientific and administrative decisions related to the Center, including the allocation of funds for new research studies and clinical trials. Aim 2. Oversee BID projects. The Administrative Core will generate annual progress reports for the NIA and work with the Roybal Coordinating Center to facilitate meetings and dissemination of knowledge. In addition, the Administrative Core will serve to help develop and identify new projects and submit new project proposals to the NIA for approval. Aim 3. Facilitate collaborative networks. The Administrative Core will encourage and facilitate the development of strategic collaborative networks among researchers, commercial interests, community interests, program design interests, and governmental entities to support translation intervention development activities. The Administrative Core, led by Dr. Gazzaley who is a well-established researcher, will draw on his extensive experience administering large, complex, collaborative, transdisciplinary grants. Dr. Gazzaley's role as the Executive Director of UCSF Neuroscape is well-aligned with this proposal, as he is already managing the development, validation, and dissemination of computer-based behavioral interventions that involve multisite collaboration across similar activities as proposed here. The UCSF teams at Neuroscape, including the Administrative Core Co-Investigators, also have experience, as demonstrated by pioneering published research studies, in assembling and managing large teams of developers, programmers, data scientists, data managers, post-doctoral fellows, and research coordinators to complete projects as proposed here.