# BID Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $925,550

## Abstract

Project Summary / Abstract: Behavioral Intervention Core
The overall goal for this Roybal Center Behavioral Intervention Development (BID) Core is to leverage
technology to facilitate memory and cognitive function so that cognitive decline may be prevented or delayed in
older adults and particularly those at-risk of Alzheimer's disease and related dementias (AD/ADRD). The
Roybal Center BID Core will conduct Stage 0 through V studies in accordance with the multidirectional,
translational NIH Stage Model, to produce potent and implementable principle-driven behavioral interventions.
At UCSF Neuroscape, we have recently demonstrated our unique ability to take an idea for a behavioral
intervention based on our previous work that elucidated brain networks enabling higher cognitive functions and
see it through all six NIH Stages for intervention development (including all three Clinical Trial Phases) en
route to FDA approval. Indeed, the first video-game based intervention we created at Neuroscape has become
the first FDA approved, prescribed video-game, which is now an important non-drug treatment option for
children with ADHD. In this vein, the BID Core will operate to achieve three aims. Aim 1. Assessment of
efficacy and effectiveness of behavioral interventions in a community setting. The proposed research
will begin with two clinical trials, each assessing a different tablet-based behavioral intervention. The two
interventions target different aspects of cognitive function that we have shown via Stage 0 research to be
deficient in advanced age and substantially impaired by dementia. Specifically, one intervention (Coherence) is
designed to challenge timing and short-term memory ability whereas the other intervention (Labyrinth) will
improve high-fidelity capability in long-term memory (LTM). Importantly, we have already demonstrated initial
efficacy and effectiveness through Stage I-IV research in healthy older adults (aged 60+ years). Here, we
propose to continue Stage III and Stage IV testing of these interventions by expanding to an older adult
population with mild cognitive impairment (MCI) and test the hypothesized mechanisms of action for these
interventions. Aim 2. Refine interventions, assess feasibility and initial efficacy in a research setting. We
have recently demonstrated virtual reality (VR) engages attention more deeply than tablet-based platforms.
Therefore, this aim will develop and assess VR-based interventions as a step towards advancing next-
generation behavioral interventions with higher efficacy. These studies constitute Stages IA (refinement), IB
(feasibility) and II (initial efficacy) of the NIH Stage Model for intervention development. Aim 3. Maintain,
expand and enhance Nexus: A modern behavioral intervention platform. We have recently created Nexus
– a HIPPA compliant web-based platform that facilitates clinical trial research through remote screening,
intervention randomization, participant tracking, and outcome assess...

## Key facts

- **NIH application ID:** 10875059
- **Project number:** 1P30AG086635-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** THEODORE P ZANTO
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $925,550
- **Award type:** 1
- **Project period:** 2024-08-15 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10875059

## Citation

> US National Institutes of Health, RePORTER application 10875059, BID Core (1P30AG086635-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10875059. Licensed CC0.

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