PROJECT SUMMARY/ABSTRACT (SHARED RESOURCE MANAGEMENT) The Rogel Cancer Center (Rogel) Shared Resources (SR) provide technical expertise, state-of-the-art technologies, data analysis, and training to meet Rogel members’ diverse scientific needs and facilitate research directed toward Rogel’s scientific themes. Rogel manages thirteen SRs and is proposing two developing SRs in this application. The SR management team, consisting of the Associate Director for SRs (ADSR), the SR Administrative Manager, and the Rogel Director of Finance, oversee SR scientific quality, accessibility, operations, budgets, and cost-effectiveness. Additionally, the management team works with Rogel members through meetings and surveys to determine members’ future SR needs and to identify those services that are no longer needed. As a member of the Rogel Senior Leadership Council, the ADSR, presents survey results and SR data to senior leadership for discussion and decisions. Examples include successful progression of the Single Cell Spatial Analysis developing SR and the Proteomics SR to full SRs; the discontinuation of computational imaging in the newly renamed and refocused Preclinical Molecular Imaging SR; and proposed establishment of the Liquid Biopsy and Epigenetics and Epigenomics developing SRs. The annual operating budget of the combined Rogel-supported SRs is approximately ~$17.6M, of which only ~$1.9M is from the Rogel CCSG, ~$1.7M is from institutional support (i.e., Medical School, Rogel, and departments), and ~$14M is from other sources (e.g., chargebacks, other grants, and contracts). Thus, the CCSG supports only ~10.8% of the overall operating expenses of the SRs demonstrating strong leveraging of these robust and diverse institutional and other funding mechanisms for Rogel SRs. During the project period, Rogel SRs successfully competed for S10 grants resulting in ~$3.9M toward the acquisition of new equipment. Rogel SRs serve all of the Rogel Research Programs resulting in support of an average of 209 publications annually, with 30% in high impact journals. To continue providing innovative and effective support to Rogel members we propose the following specific aims: (Aim 1) Provide relevant, distinctive, and innovative expertise and services that enhance research capability and members’ collaborations; (Aim 2) Ensure accessibility, stability, reliability, quality, accountability, and cost effectiveness of SRs; (Aim 3) Forecast and meet future scientific SR needs of Rogel members. We will achieve these aims through a combination of communication with users and SR staff; critical evaluation of SR-relevant metrics; and input from senior leadership, Program leaders and advisory boards. Through these activities, Rogel SRs will continue to provide services that are critical to Rogel member research and to the Rogel mission.