# Protocol Review and Monitoring System

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $353,761

## Abstract

PROJECT SUMMARY/ABSTRACT (PROTOCOL REVIEW AND MONITORING SYSTEM)
The primary responsibility for the Protocol Review and Monitoring System (PRMS) rests with the University of
Michigan Health Rogel Cancer Center (Rogel) Protocol Review Committee (PRC). The PRC is aided in its pursuit
of the PRMS Specific Aims by the Clinical Research Teams (CRT) which have specific, non-overlapping, and
well-defined roles. All cancer protocols undergo two-stage review, starting with the CRT review and the
culminating with PRC review.
CRTs are disease- and domain-oriented groups in the Rogel that serve as the nidus for patient-oriented research.
CRTs are led by mid-career and senior clinical investigators who have an academic primary focus on clinical
research, have significant experience as principal investigators on interventional cancer clinical trials (with
particular emphasis on investigator-initiated trials), and see patients in the clinics associated with their respective
disease team. The CRTs are charged with reviewing and prioritizing proposed cancer clinical trials within their
respective disease/domain that arise from the scientific themes in the Rogel Programs and elsewhere, both to
ensure scientific merit, and to increase the chances of success in implementation.
The PRC, which is comprised of experts in clinical research from diverse disciplines, provides independent peer
review of the scientific merit and feasibility of new cancer-related clinical protocols. It also monitors the scientific
progress of activated protocols to ensure that they continue to be of high scientific merit and priority, support the
Rogel research mission, and achieve accrual goals in a realistic timeframe. By providing this level of exceptional
peer-review oversight of cancer clinical research, PRMS helps to ensure that Rogel conducts high quality
protocols that are scientifically impactful, realize their accrual targets, and utilize Rogel resources wisely.

## Key facts

- **NIH application ID:** 10875476
- **Project number:** 5P30CA046592-35
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Kyle C. Cuneo
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $353,761
- **Award type:** 5
- **Project period:** 1997-06-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10875476

## Citation

> US National Institutes of Health, RePORTER application 10875476, Protocol Review and Monitoring System (5P30CA046592-35). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10875476. Licensed CC0.

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