# Pharmacokinetics (PK)

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $201,830

## Abstract

PROJECT SUMMARY/ABSTRACT (PHARMACOKINETICS SHARED RESOURCE)
The Pharmacokinetics Shared Resource (PK-SR) was founded in 2009 and has been funded by the CCSG since
2012. PK-SR is led by Co-Directors Duxin Sun (DT) and Amit Pai (DT) with eleven full time staff members and
eight LC-MS instruments. PK-SR plays a pivotal role in advancing the drug discovery, drug optimization, and
clinical translation of novel anti-cancer therapeutics. PK-SR has a thirteen-year track record of supporting lead
compound selection in cancer drug discovery/optimization based on in vitro and in vivo ADME (absorption,
distribution, metabolism, and excretion) and preclinical pharmacokinetic (PK) platforms. The strong bioanalytical
and PK knowledge of the SR also supports the clinical PK needs of investigators performing phase I/II clinical
trials in patients. Rogel Cancer Center (Rogel) members benefit from the resources and strategic advice offered.
PK-SR plays a pivotal role in guiding key experimental decisions to help streamline studies to maximize
information gain at the lowest cost. This approach has contributed to major scientific advancements led by Rogel
members. PK-SR operates based on an academic research organization framework to rapidly inform go or no-
go decisions on key compounds under investigation by Rogel members. PK-SR also collaborates on joint grant
and patent applications and helps generate high-impact publications.

## Key facts

- **NIH application ID:** 10875491
- **Project number:** 5P30CA046592-35
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** DUXIN SUN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $201,830
- **Award type:** 5
- **Project period:** 1997-06-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10875491

## Citation

> US National Institutes of Health, RePORTER application 10875491, Pharmacokinetics (PK) (5P30CA046592-35). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10875491. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*