# Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's Disease

> **NIH NIH R01** · RENSSELAER POLYTECHNIC INSTITUTE · 2024 · $554,778

## Abstract

Neurofibrillary tangles (NFT) is a pathological hallmark of Alzheimer’s disease (AD). NFT is composed of
aggregated tau protein and is correlated to cognitive decline in dementia progression. NFT spreads in the brain
in a prion-like manner, mediated by the interaction between tau and neuronal surface glycans. The long-term
goal is to study the structural details of tau-glycan interaction and to discover drugs to disrupt this interaction
for disease-modifying treatment of AD. In this proposal, we will study the tau-heparan sulfate interaction from
at the molecular (aim 1), the cellular (aim 2), and organismal level and carry out drug discovery (aim 3).

## Key facts

- **NIH application ID:** 10875754
- **Project number:** 4R01AG069039-02
- **Recipient organization:** RENSSELAER POLYTECHNIC INSTITUTE
- **Principal Investigator:** ROBERT J LINHARDT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $554,778
- **Award type:** 4N
- **Project period:** 2020-09-15 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10875754

## Citation

> US National Institutes of Health, RePORTER application 10875754, Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's Disease (4R01AG069039-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10875754. Licensed CC0.

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