# Fox COBRE Phase II Admin Core

> **NIH NIH P20** · UNIVERSITY OF DELAWARE · 2024 · $1,343,022

## Abstract

Project Summary 
Administrative Core 
This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to 
discover and apply new chemical biology tools for the study of biological pathways associated with disease, and 
to develop computational approaches for understanding small molecule interactions with complex 
macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new 
chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to 
survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of 
infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl 
eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that 
yield specific immune responses in the lung to advance inhalable vaccine development, and computational 
approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus 
capsids. 
The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of 
the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of 
summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC), 
mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that 
enables faculty to develop successful research programs and to attract funding for their work; (4) Development 
of research, training & career development goals and capabilities. A plan for hiring and retaining successful 
faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core 
facilities and participation in COBRE sponsored events.

## Key facts

- **NIH application ID:** 10876432
- **Project number:** 5P20GM104316-10
- **Recipient organization:** UNIVERSITY OF DELAWARE
- **Principal Investigator:** JOSEPH M FOX
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,343,022
- **Award type:** 5
- **Project period:** 2014-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10876432

## Citation

> US National Institutes of Health, RePORTER application 10876432, Fox COBRE Phase II Admin Core (5P20GM104316-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10876432. Licensed CC0.

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