PROJECT SUMMARY – ADMINISTRATIVE CORE The Administrative Core of the CONNECT Integration and Coordination Center (ICC), led by Prof. Jake Chen and Dr. Swathi Thaker from the University of Alabama at Birmingham (UAB), is dedicated to driving the success of the Common Fund Data Ecosystem (CFDE) through innovative and impactful initiatives. Our core team at UAB focuses on efficient operations, transparent communication, and continuous improvement in team science practices to revolutionize biomedical research. By developing comprehensive operation guidelines and engagement protocols, we ensure seamless integration and coordination within the CFDE, fostering effective collaboration and maximizing research impact. Leveraging our expertise in agile project management and the cutting-edge U-BRITE platform, we optimize workflows, enhance communication, and allocate resources efficiently, pushing the boundaries of research efficiency and innovation. Through CFDE annual meetings, multidisciplinary seminar series, and showcases for CF products, we facilitate information exchange, foster collaboration, and promote the rapid dissemination and discussion of research findings. Our annual CONNECT hackathon brings together diverse teams to tackle complex challenges, fostering innovation and pushing the boundaries of scientific discovery. Engaging with CFDE stakeholders and gathering valuable feedback, we continuously assess and refine our operations to meet the evolving needs of the scientific community. Our work is not only significant in driving the success of the CFDE but also innovative in its approach, integrating advanced agile project management and team-based online communication software, promoting open collaboration, and enhancing research outcomes. Through our commitment to excellence, we strive to revolutionize biomedical research, catalyze breakthrough discoveries, and improve health outcomes for all.