There is increasing evidence of a dual epidemic of HIV and violence occurring in intimate relationships between men (IPV), yet understanding of the synergies between these two epidemics is underdeveloped. Estimated prevalence for receipt of IPV in this population (GBM) range from 12% to 78%. Emergent evidence demonstrates associations between the experience of IPV among GBM and participation in behaviors that heighten the chance of acquiring HIV. Beyond the indirect behavioral associations between IPV and HIV, less is known about direct pathways through which IPV may increase HIV acquisition among GBM. According to Schafer’s theoretical model, IPV not only contributes to behavioral risk, but also to immunologic change that impacts this risk – but all of this evidence comes from studies that do not include men. With the identification of HIV-specific immunologic dysfunction associated with IPV, we are able to further investigate upstream factors, including psychological stressors that may contribute to such changes, as well as protective measures such as coping and resiliency processes. We hypothesize that experiences of IPV, in the context of stressors, increase both indirect behavioral and direct biological and immunologic risks for HIV infection among men. To fill this critical gap in knowledge, we propose an innovative 24-month cohort study of partnered HIV-negative men in SE Michigan, to identify the pathways and points of intervention between IPV and HIV risk for GBM. Prior research is limited by cross-sectional designs, inconsistent measures of violence, and inattention to important psychosocial and structural factors that co-occur with both IPV and HIV and may moderate or mediate relationships. We address these limitations by employing a rigorous cohort design, measures of IPV that are specific to this population, and consider the multiple stressors and stress response behaviors that may shape both IPV and HIV risk behaviors, and measures of HIV-specific immunologic dysfunction, biological risk, and behavioral risk. The proposed research activities include a prospective 24-month cohort of HIV-negative partnered men (≥18 years) recruited in SE Michigan. The overall aim of the proposed activities is to provide new knowledge of how IPV shapes engagement in HIV prevention and risk factors.