# Tissue and Pathology Core

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2024 · $204,515

## Abstract

Project Summary/Abstract 
The goal of the Pathology Core is to facilitate the histopathologic and molecular analysis of human breast tissues 
and provide pathology expertise to the PPG Projects. Results derived from human tissue-based studies will allow 
PPG investigators to extend the findings from pre-clinical investigations to human disease. The PPG Pathology 
Core has two aims: Aim 1: To facilitate the acquisition of human breast tissues for use by PPG investigators; 
and Aim 2: To provide collaborative research pathology expertise to PPG investigators, including advice on 
characteristics of human breast cancer, immunohistochemistry and other morphologically-directed assays as 
well as histopathologic evaluation of human and mouse tissues. 
The PPG Pathology Core supplements the existing Breast Biospecimen Repository that currently serves as the 
main tissue and pathology resource for the Dana Farber/Harvard Cancer Center (DF/HCC) breast cancer 
research community. The PPG Pathology Core Director, Dr. Deborah Dillon, is a breast and molecular 
pathologist at Brigham and Women’s Hospital (BWH)/Dana Farber Cancer Institute (DFCI) with particular interest 
in tissue-based evaluation of standard and novel molecular markers. Through the PPG Pathology Core, she will 
devote effort specifically to the needs of the PPG Projects, providing pathology expertise and support to 
investigators incorporating human tissue analysis into their studies. 
The PPG Pathology Core supports pathology collaboration specific to the PPG Projects above and beyond the 
general tissue and pathology resources available to the DF/HCC breast cancer research community. The Breast 
Biospecimen Repository and the SPORE in Breast Cancer provide a strong foundation for tissue and data 
collection, storage and distribution within the larger DF/HCC community, but do not specifically include pathology 
collaborations with PPG investigators. The budget for the PPG Pathology Core covers the additional effort 
needed for pathology collaboration, tissue retrieval and analysis specific to the PPG projects.

## Key facts

- **NIH application ID:** 10876974
- **Project number:** 5P01CA250959-05
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** Deborah A. Dillon
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $204,515
- **Award type:** 5
- **Project period:** 2020-09-11 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10876974

## Citation

> US National Institutes of Health, RePORTER application 10876974, Tissue and Pathology Core (5P01CA250959-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10876974. Licensed CC0.

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