# Surface Plasmon Resonance to Measure Biomolecular Interaction at Fresno State

> **NIH NIH S10** · CALIFORNIA STATE UNIVERSITY FRESNO · 2024 · $242,073

## Abstract

PROJECT SUMAMRY/ABSTRACT
The Nicoya Alto is a surface plasmon resonance (SPR) instrument platform for measuring the kinetics and affinity
of protein-protein and protein-ligand interactions. SPR has become the standard approach for measuring protein
interactions and has broad applications in protein science and drug discovery. This instrument is capable of real-
time kinetic measurements using very low sample amounts. The long-term objective of this application is to
provide the infrastructure needed to measure biomolecular interactions at Fresno State. The users of this
instrument propose multi-disciplinary research and educational projects that measure protein interactions in a
range of applications including: antibody engineering, cancer drug discovery, anti-bacterial peptides, and protein
nanomaterials. The Nicoya Alto instrument will also be used in an educational capacity to train a generation of
undergraduate students in the fundamentals of protein structure relationships and quantitative binding. Fresno
State is a minority serving institution located in California’s central valley, we serve a population of
underrepresented minorities and 1st generations college students. Access to a state of the art- SPR instrument
will help the College of Science and Math’s serve this important student population and meet its strategic goal
of preparing the next generation of STEM professionals though innovation and discovery. The instrument will
bring new biomedical research capabilities to Fresno State, benefiting our diverse student population, enabling
the measurement of protein interactions in a variety of research and educational contexts.

## Key facts

- **NIH application ID:** 10877333
- **Project number:** 1S10GM154208-01
- **Recipient organization:** CALIFORNIA STATE UNIVERSITY FRESNO
- **Principal Investigator:** Cory Brooks
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $242,073
- **Award type:** 1
- **Project period:** 2024-06-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10877333

## Citation

> US National Institutes of Health, RePORTER application 10877333, Surface Plasmon Resonance to Measure Biomolecular Interaction at Fresno State (1S10GM154208-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10877333. Licensed CC0.

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