# Mechanisms underlying reversal of cardiac aging by urolithin a treatment

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2024 · $647,672

## Abstract

PROJECT SUMMARY/ABSTRACT
Aging is one of the greatest risk factors for the development of cardiovascular disease and heart failure.
Mitochondrial dysfunction in the aging heart is thought to be an important contributing factor to the decline in
cardiovascular function with age, including hypertrophy and left ventricular wall thickness, diastolic dysfunction,
and reduced contractility and calcium dynamics that contribute to the increased risk for clinically important
cardiovascular disease. Despite the growing interest in the mitochondrial biology of aging and the clear clinical
and

## Key facts

- **NIH application ID:** 10877344
- **Project number:** 1R01AG081395-01A1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** David J. Marcinek
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $647,672
- **Award type:** 1
- **Project period:** 2024-09-15 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10877344

## Citation

> US National Institutes of Health, RePORTER application 10877344, Mechanisms underlying reversal of cardiac aging by urolithin a treatment (1R01AG081395-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10877344. Licensed CC0.

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