# Translation Core

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $194,253

## Abstract

Abstract (Translation Core) 
The Translation Core will serve the needs of IDRC affiliated investigators whose research programs require 
measurements in human subjects or tissues. The Director (Dr. K. Mather) and Associate Directors (Dr. R. 
Considine and S. Tersey) of this Core bring specific expertise in the design and performance of in vivo 
measurements for physiologic, translational and proof-of-principle studies in humans. The Translation Core is 
not only essential for the work of a number of established clinical investigators at Indiana University School of 
Medicine (IUSM) and its affiliated instituions, but is also an important conduit facilitating entry into the field of 
diabetes research for investigators not traditionally working with human subjects or human subjects materials. 
The Specific Aims of the Core include: 
 (1) To enable pre-clinical and clinical IDRC investigators to evaluate in humans various molecular and 
physiologic advances made in model systems through access to banked human tissues and in vivo human 
studies. 
 (2) To maintain and augment readily accessible tissue sample banks from human subjects 
participating in metabolic studies for use by all IDRC investigators. 
 (3) To assist in the design, performance, and interpretation of human subjects studies applying 
appropriate scientific rigor and statistical methodologies, as well as providing detailed measurements of 
metabolic physiology in humans. 
 (4) To provide IDRC core laboratory functions that support high-quality, high-throughput, low-cost 
measurements of circulating hormones, cytokines, and standard chemical analytes of interest to multiple IDRC 
investigators, measuring samples from human, animal and cultured cell studies. 
( 5) To provide training to IDRC investigators, fellows and students in the design and conduct of human 
translational experimentation. 
 (6) To actively collaborate with IDRC investigators, making available novel measurements and novel 
methodologies as they apply to human translation studies, including systematically assessing their relevance 
to human biology and disease using the Translation Core stepped approach. 
 It is anticipated that the Translation Core will augment substantially the research capacity of the 
investigators in the IDRC by providing a conduit for the translation of key findings to humans.

## Key facts

- **NIH application ID:** 10877695
- **Project number:** 5P30DK097512-10
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Tamara S Hannon
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $194,253
- **Award type:** 5
- **Project period:** 2015-07-06 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10877695

## Citation

> US National Institutes of Health, RePORTER application 10877695, Translation Core (5P30DK097512-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10877695. Licensed CC0.

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