Project Summary/Abstract Research: While effective measurement of the patient’s perspective on their illness and its treatment provides complimentary information to objective disease severity, patient-reported outcomes capturing the lived experience of chronic inflammatory skin disease are rarely used in routine dermatology practice. Item response theory techniques can enable more efficient administration of patient-reported outcomes in the clinic, which can address barriers such as time to administer these measures. The purpose of this study is to 1. prioritize the outcome domains that are most meaningful to individuals with chronic inflammatory skin diseases such as acne, psoriasis, and atopic dermatitis; 2. evaluate the content validity of a novel Patient-Reported Outcomes Measurement Information System (PROMIS) profile measuring these domains; 3. field test and evaluate the validity of a novel PROMIS profile to capture the lived experience of chronic inflammatory skin disease. The overall objectives of this K23 award proposal are to improve the care of patients with chronic inflammatory skin diseases by developing a practical patient-reported outcome to measure the lived experience of these skin diseases, which will enable increased use of patient-reported outcomes in routine clinical care. Candidate: Dr. Barbieri’s long-term career goal is to become an independent, patient-oriented physician- scientist, with a focus on chronic inflammatory skin diseases, patient-reported outcomes, and health services research. His prior training has provided him with a foundational background in these areas. Environment: During the award period Dr. Barbieri will devote 80% of his time to clinical research and 20% to the clinical care of patients with chronic inflammatory skin disease such as acne, atopic dermatitis, and psoriasis. Dr. Margolis and Dr. Pusic, the candidate’s primary mentors, have directly supervised the training of numerous successful junior faculty members and Dr. Barbieri will benefit from his experience and enthusiasm for cultivating the careers of junior scientists. The Brigham and Women’s Hospital offers a rich training environment, including resources and expertise available in the Clinical Unit for Research Innovation and Trials (CUReIT) and Patient-Reported Outcomes, Value & Experience (PROVE) Center. Combined with the knowledge and expertise available in the Department of Dermatology and in Dr. Margolis’s and Dr. Pusic’s labs, these opportunities will provide an unparalleled opportunity to begin a career as a physician scientist. Career Development: With the support of his advisory committee, Dr. Barbieri’s training will focus on advanced psychometric techniques and qualitative research to develop a strong knowledge base with respect to patient-reported outcome development and validation. Completion of the proposed research and career development plan will give Dr. Barbieri the knowledge and skills to achieve scientific independence,...