# Core B. Biostatistics, Bioinformatics and Genetic Analysis (BBGA)

> **NIH NIH P30** · OHIO STATE UNIVERSITY · 2024 · $143,005

## Abstract

Abstract: CORE B. BIOSTATISTICS, BIOINFORMATICS AND GENETIC ANALYSIS (BBGA)
The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established scientific
connections among the vision researchers across five academic units (i.e., College of Medicine (COM),
College of Optometry (COO), College of Engineering, College of Veterinary Medicine, College of Arts and
Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has support
and commitment from Deans and Chairs for equipment, data science, space, new and existing programs to
enhance collaborations among NEI-funded PIs, facilitate gathering pilot data for future PIs, and subsidizes cost
for access to the High-Performance Computing Cluster (HPCC) that is maintained by the Ohio Supercomputer
Center (OSC), which is relevant for Core B. The synergy among the vision research community has been
established with a monthly meeting group called ViSOR (Vision Sciences OSU Research). Synergy between
the Cores has been defined with a Steering Committee, which is composed of the PD, Core Directors and Co-
directors. This synergy between Cores will coincide with the monthly ViSOR meetings, and ad hoc as needed
for operational issues and future equipment purchases. In addition, an Advisory Group has been established to
give guidance to the Steering Committee. Core B, BBGA Core has two aims: Aim 1. Provide analytical
assistance for analyses of vision research data. The BBGA Core will provide analytical expertise for
research data arising from clinic-based and genetic studies, such as whole-exome sequence, whole-genome
sequencing, bulk RNA-Seq, and scRNA-Seq projects. The biostatistics staff will work with investigators of
clinical research projects to design well-powered studies; assist in data management; and provide rigorous
statistical analysis, including the appropriate methodology to deal with the intricacies of the correlation of two
eyes. Aim 2. Provide consultation, training, and access to specialized software for genetic analyses of
vision research data. The BBGA Core Director and staff will provide tailored consultations to users for
planning and conducting their genetics research and analyses. Best practices will be promoted for study
design, sample size estimation, and power calculation for bioinformatic and genetic components of grant
applications. Training in the use of and access to specialized software for genetics and genomics analyses will
be available. The added values are access to skilled experts in vision science genetics, the latest computation
facilities, and specialized software for genetic analysis. This proposed P30 Core B, BBGA intends to maximize
efficiency, offer centralized access to equipment and expertise that would be difficult, costly or impractical to
duplicate in individual labs, and use protocols to ensure best practices to perform science at the highest
standard. The expected outcome is increased collaboration for s...

## Key facts

- **NIH application ID:** 10878926
- **Project number:** 5P30EY032857-03
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Xiaoyi Raymond Gao
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $143,005
- **Award type:** 5
- **Project period:** 2022-09-30 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10878926

## Citation

> US National Institutes of Health, RePORTER application 10878926, Core B. Biostatistics, Bioinformatics and Genetic Analysis (BBGA) (5P30EY032857-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10878926. Licensed CC0.

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