ABSTRACT Overall Component The Visual Sciences Research Center (VSRC) at Case Western Reserve University (CWRU) requests continuing support for a P30 Core Grant for Vision Research. The VSRC was founded in 1996 and has undergone tremendous growth since the first P30 grant award in 1997 and subsequent grant renewals in 2002, 2007, 2011, and 2016. The CWRU P30 Core Grant has enhanced and expanded individual investigators’ programs, facilitated inter-investigator and inter-departmental collaborations, and helped bring new investigators within CWRU to the visual sciences, both junior and established. Our VSRC is now comprised of 36 PIs in 13 clinical and basic science departments from the two CWRU Schools and the CWRU College of Arts and Sciences. These investigators conduct innovative, impactful, and interdisciplinary research on fundamental mechanisms in the retina, causes and treatment of common retinal diseases as well as study normal and pathologic processes in the anterior segment of the eye. Our current NEI grant portfolio is diverse and encompasses many funding mechanisms. These include 14 eligible NEI R01s, 1 NEI UG1, 3 NEI R21s, 1 NEI T32, and 2 NEI F30 grants. In addition, our VSRC investigators hold 20 grants from other NIH Institutes. The VSRC is strongly supported by the CWRU School of Medicine, University Hospitals Cleveland Case Medical Center, and the CWRU Department of Ophthalmology and Visual Sciences, which provide significant funds for bringing new PIs to vision research, repair and purchase equipment, service contracts, a partial salary support of the core managers as well as on the seminar series and annual VSRC symposiums. We request support for the 3 resource Cores: 1) Specialized Animal Resources; 2) Molecular Biology and Genotyping; and 3) Analytical Services. All three Cores are expected to be heavily utilized and lead to successful accomplishment of the three unifying grant’s Specific Aims: 1) to enhance the capabilities and productivity of the eligible NEI R01 holders as well as other VSRC investigators by providing them with services, resources and facilities that are too costly for an individual laboratory; 2) to increase scientific interactions among the VSRC investigators by sharing resources and expertise; 3) to bring new investigators to vision research, both junior and established.