PROJECT ABSTRACT The goal of the Center for Redox Biology and Cardiovascular Disease CoBRE is to establish a nationally recognized advanced research and training program facilitating the development of junior faculty research to major independent research funding in the area of redox biology and cardiovascular pathophysiology. In order to accomplish this goal, a multifaceted plan for research program development along with mentorship and training is required. The Administration Core A provides implementation and management all CoBRE program initiatives including advanced research core facilities, mentorship program for junior faculty development, External and Internal Advisory Committees along with a Senior Mentoring Committee, an annual scientific colloquium, continuing education, and formal evaluation procedures, and the pilot grant mechanism that supports development of promising projects from junior faculty. The Administration Core is managed by the CoBRE PI along with coordinator assistance, and business management oversight of the program budget. This core will centralize all CoBRE program documentation and reporting in compliance with NIGMS CoBRE requirements.