# Cystathionine Gamma Lyase (CSE) and Hydrogen Sulfide Regulation of Vascular Aging

> **NIH NIH P20** · LOUISIANA STATE UNIV HSC SHREVEPORT · 2024 · $219,000

## Abstract

PROJECT ABSTRACT
Aging is an independent risk factor for cardiovascular diseases. Altered molecular signaling in age-related
markers leads to increased ROS, ER stress, autophagy defects, endothelial dysfunction and subsequently,
impaired vascular remodeling. However, the regulatory mechanisms, and the role of CSE/H2S signaling in
vascular remodeling and associated functions in aging are unknown. The current proposal will reveal novel
information regarding CSE/H2S regulation on endothelial function and aging vasculature by investigating the
hypothesis that endothelial-cell CSE deficiency in aging, and subsequently reduced H2S/NO bioavailability
impairs vascular remodeling. This hypothesis will be examined by two specific aims that 1. identify the molecular
mechanisms of reduced CSE/H2S deficiency in aging and 2. determine reduced endothelial CSE/H2S effects on
age-associated vascular dysfunction. The goal of this proposal is to generate preliminary data towards at least
two high impact peer-reviewed manuscript and submit my R01 by end of 2024.

## Key facts

- **NIH application ID:** 10879024
- **Project number:** 5P20GM121307-07
- **Recipient organization:** LOUISIANA STATE UNIV HSC SHREVEPORT
- **Principal Investigator:** Gopi K Kolluru
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $219,000
- **Award type:** 5
- **Project period:** 2023-08-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10879024

## Citation

> US National Institutes of Health, RePORTER application 10879024, Cystathionine Gamma Lyase (CSE) and Hydrogen Sulfide Regulation of Vascular Aging (5P20GM121307-07). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10879024. Licensed CC0.

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