# Mobile adaptive intervention to reduce negative consequences associated with simultaneous alcohol and marijuana use in young adults in primary care

> **NIH NIH R34** · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $235,241

## Abstract

Project Summary
Up to one-third of young adults report use of marijuana or alcohol in the past month, with 8% reporting daily
marijuana use and 32% engaging in heavy episodic drinking. Marijuana and alcohol use peak during emerging
adulthood and can still have an impact on the developing brain. Both substances are associated with lower
academic achievement, negative health effects, addiction, and driving impairment and injury. Simultaneous
alcohol and marijuana (SAM) use, defined as use of both substances at the same time or in close proximation
of each other with overlapping effects, is common among young adults. Past research has shown that SAM
use occurs in almost one-fourth of young adults and can lead to more negative consequences than use of
either substance alone. Though brief interventions have been developed for alcohol and marijuana use
independently, many are targeted to college populations. Young adults in the community who are at risk for
developing substance use disorders (SUDs) often have more limited options. Targeting protective behavioral
strategies (PBS), such as setting limits on the frequency of SAM use, may help reduce negative consequences
and prevent development of SUD. No current intervention addresses SAM use and few leverage new
technological methods (e.g., smartphones) or strategies (e.g., PBS) to engage young adults. Ecological
momentary interventions (EMIs) and just-in-time adaptive interventions (JITAIs) offer opportunity for
interventions on SAM use by delivering intervention components in real-time, in a person's natural
environment, using mobile devices. Technological advances afford increased adaptability to support an
individual as his/her context changes, when the individual is receptive and in need of assistance. The goal of
this treatment development project is to develop an adaptive EMI (a-EMI) that is grounded in self-regulation
and social cognitive theories. To determine the most efficacious intervention strategies, we will utilize the
Multiphase Optimization Strategy (MOST) framework. Historically, most interventions are built initially as a
package of strategies, from which it is difficult to determine the most effective components. As an alternative,
the MOST framework allows for successive testing of intervention components to identify the best combination.
Following pilot testing, we will assess the feasibility and efficacy of intervention components on two outcomes
(negative consequences and PBS) using a fractional factorial experimental design, with post-assessment and
one- and three-month follow-ups. 136 diverse young adults recruited from primary care clinics who report
current SAM use will be randomly assigned to one of eight groups, representing experimental conditions that
include or do not include intervention strategies focused on craving reduction and PBS. As a result of this
process, individual and/or combined components that lead to improved outcomes will be retained in a
subsequent rando...

## Key facts

- **NIH application ID:** 10879164
- **Project number:** 5R34DA056759-03
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Kristina T. Phillips
- **Activity code:** R34 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $235,241
- **Award type:** 5
- **Project period:** 2022-08-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10879164

## Citation

> US National Institutes of Health, RePORTER application 10879164, Mobile adaptive intervention to reduce negative consequences associated with simultaneous alcohol and marijuana use in young adults in primary care (5R34DA056759-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10879164. Licensed CC0.

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