# Continued Development and Maintenance of the UltraScan Software

> **NIH NIH R01** · UNIVERSITY OF MONTANA · 2024 · $334,353

## Abstract

Project Summary/Abstract
We propose to continue development and support for the free and open source UltraScan-III (US3) software
suite and develop new code and methods to address challenging biomedical research questions that can be
solved with the latest instruments available for analytical ultracentrifugation and at beamlines for small-angle
X-ray and neutron scattering experiments (SAXS/SANS) experiments. UltraScan is a comprehensive toolkit for
the analysis of data from hydrodynamic experiments and simulations. Such experiments include analytical
ultracentrifugation and solution bio-SAXS/SANS, as well as bead modeling simulations. Support for this project
will assure continued availability of a mature multi-platform analysis suite with important and unique capabilities
not found in any other software packages. Chief among them are tight integration of supercomputing
capabilities, LIMS support for collaboration, and specialized analysis routines. US3 enjoys world-wide use in
the AUC and SAXS/SANS communities, and offers the most robust optimization and simulation algorithms
available, resulting in unmatched detail. UltraScan provides the highest throughput, a flexible, modern GUI,
and a comprehensive list of analysis routines. Proposed new developments include improved automation for
data acquisition, analysis, and reporting workflows, and new tools to support electronic signatures and audit
trails to satisfy 21 CFR Part 11 requirements. These developments will increase the reliability and rigor of
UltraScan analysis, and improve safety for patients by assuring reproducibility of therapeutic drug
characterization by AUC.

## Key facts

- **NIH application ID:** 10879307
- **Project number:** 2R01GM120600-09
- **Recipient organization:** UNIVERSITY OF MONTANA
- **Principal Investigator:** Emre H. Brookes
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $334,353
- **Award type:** 2
- **Project period:** 2016-08-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10879307

## Citation

> US National Institutes of Health, RePORTER application 10879307, Continued Development and Maintenance of the UltraScan Software (2R01GM120600-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10879307. Licensed CC0.

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