P30 _ CCDI_Data UseSupplement TITLE: Pilot study to link clinical and imaging data from the electronic medical record (EMR), Children's Brain Tumor Network (CBTN) and the Molecular Characterization Initiative (MCI). ABSTRACT: The launch of the Molecular Characterization Initiative (MCI) provides an unprecedented resource of molecular data on children with newly diagnosed cancers, including over 1000 participants with primary tumors of the central nervous system (CNS) in the first year. The Children's Brain Tumor Network (CBTN) is a consortium of institutions committed to genomic characterization and clinical data collection and sharing through open access platforms. The CBTN has collected longitudinal clinical and biological data on over 5000 participants with CNS tumors over the past decade, data which is shared in open cloud-based platforms. Seattle Children's Hospital as part of the Fred Hutch/UW comprehensive cancer center is uniquely positioned as a founding member of CBTN and the highest enrolling site on MCI to conduct the pilot study proposed to 1) develop a pipeline to automate data extraction from the electronic medical record in partnership with CBTN and Amazon Web Services (AWS) teams, 2) increase imaging data available through CBTN and CCDI and 3) connect CBTN and MCI data at the participant level. The tools, processes and pipelines developed in this pilot may be rapidly expanded to other institutions to greatly increase the impact of the CCDI as a rich resource for the pediatric cancer research community.