Project Summary The overall goals of this P20 application are (1) to identify ancestry-specific genetic regulators of macrophage function and response to anti-HER2 antibody therapy that potentially underlie racial differences in response to this targeted immunotherapy and (2) to establish a robust infrastructure to support and develop innovative, productive immuno-oncology and health disparities research collaborations. The Administrative Core facilitates this goal by providing an overall organizational infrastructure, integration with existing CCSG-supported Cancer Center resources, a system for financial management, and overall governance. Specifically, the Administrative Core provides the overall leadership, management, and coordination of all Research Project activities and facilitates the meetings of the Executive Committee, Planning Committee, and Internal Advisory Committee. All official communications among P20 participants originate from the Administrative Core. Specifically, the aims of the Administrative Core are to provide leadership and oversight of all P20 activities by (1) convening an Executive Committee for monthly progress review, including monitoring of specific timeline/milestones for Project and Planning Committee deliverables, (2) providing fiscal and resource management for each component of the P20, (3) ensuring compliance with all NIH and institutional grant regulations, and (4) facilitating communications between P20 investigators and the National Cancer Institute. We will also facilitate the development of multidisciplinary collaborations and grant proposals in immuno-oncology and health disparities by establishing a Planning Committee with cross-cutting expertise in cancer immunology, molecular epidemiology, social determinants of health, and translational science and implement a structured process for developing multiple extramural grant proposals. Finally, we will support integration of health disparities and immuno-oncology research into the Cancer Center overall by convening an Internal Advisory Committee (IAC) to ensure program integration and optimization of resources from the comprehensive cancer center.