ABSTRACT Building on over 30 years of close collaboration between the Core Leader (Professor Maislin) and Program Project Director (Dr. Allan Pack), as well as long-standing collaborations among other Project Investigators and members of the Core, the Biostatistics and Data Analysis Core (Core B) will play a crucial role in this Program. Primary responsibilities of the Core include to promote good scientific practice in the conduct of the research protocols, to implement statistical and machine learning analyses relevant to each Project's aims, to adapt methods or develop novel approaches where necessary, to collaborate with the Data Integration Core in data collection, management and analysis, to provide expert statistical programing using specialized software, and to ensure the fair, accurate, and unbiased publication of research findings from this Program Project.