PROJECT SUMMARY/ABSTRACT The primary objective of this proposal is to continue our longstanding (45yr) cardiopulmonary research training efforts at the University of Colorado Anschutz Medical Campus (CUAMC). This program trains individuals with doctoral degrees in either biological or medical sciences for successful careers in research. A multidisciplinary team-oriented approach to both mentoring and training emphasizing the integration of studies at the molecular, cellular, tissue organ, and physiological (whole organism) levels permits rapid bench-to-bedside-to-bench translation of the work performed. Our program is continually evolving. We expanded the focus to include access to genomics and transcriptomics expertise through the Genomic Shared Resource Center and to advanced computational skills through a new Center for Health Artificial Intelligence. These additions complement our focus in Bioengineering, Biomaterials, Regenerative Medicine, Genomics, Metabolomics and Redox Biology. Collectively, this expanded focus enables us to involve outstanding programs and investigators whose work directly intersects with cardiopulmonary biology. Of the many training grants at CUAMC, this is the only one specifically dedicated to pulmonary vascular biology and one of only 2 in the country focusing on this area. Our continuing and long-term goal is that after 3 years of training the program’s fellows will have acquired the professional skills to be competitive for research and/or teaching positions and obtain their own extramural funds. Toward this end, we have added outstanding new scientific and educational mentors. Further, Dr. Flores has been appointed multiple PI and brings great strength to our program as Vice Chair of Diversity and Justice for the Department of Medicine. Our specific objectives are: 1)To attract and select talented and highly motivated fellows who have a demonstrated interest in cardiovascular and pulmonary diseases. 2)To provide trainees with an intensive research experience by pairing them with mentors who are rigorously selected based on their qualifications. 3)To enhance the scientific knowledge and critical thinking abilities by requiring a series of formal workshops/lectures. 4)To enhance multidisciplinary, collaborative approaches to research by requiring co- mentors and a Team-oriented T-shaped Development for T-32 Trainees (T4) approach. 5)Train fellows in responsible and ethical conduct of research. 6)To help the trainees/scientists develop proficiency with a wide array of non-bench professional skills necessary for biomedical research careers such as communication, leadership development, and project management and professionalism. 7)To introduce our fellows to a suite of social science theories and provide instruction on how to navigate biases and microaggressions in academia. The increasing national and international interest in pulmonary vascular biology, the expanded nature of our program, and the excellent track re...