Interrogating Mechanisms of Anti-tumor Immunity in Human Subjects and Murine Models of IDH-Mutant Glioma Treated with All-Trans Retinoic Acid and PD-1 Inhibition
Abstract
Project Abstract
Diffuse gliomas are fatal brain tumors that respond poorly to current immunotherapies. Using
both mice models and human clinical trial data, we propose a series of experiments to identify
immune biomarkers and key immune cell types that predict tumor responsiveness to therapy.
These results will further our understanding of brain tumor biology and inform the future
development of new treatment modalities.
Key facts
- NIH application ID
- 10880594
- Project number
- 5R37CA284132-02
- Recipient
- UNIVERSITY OF PENNSYLVANIA
- Principal Investigator
- Nduka Mgbechinyere Amankulor
- Activity code
- R37
- Funding institute
- NIH
- Fiscal year
- 2024
- Award amount
- $689,044
- Award type
- 5
- Project period
- 2023-07-03 → 2028-06-30