# Improving the delivery and equity of inpatient palliative care: a hybrid type I pragmatic cluster trial

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 2024 · $690,884

## Abstract

PROJECT SUMMARY
Millions of Americans living with serious illness experience burdensome symptoms and receive aggressive
care that is not aligned with their goals and preferences. Palliative care, which entails a supportive approach to
care focused on maximizing quality of life, improves patient-centered, clinical, and economic outcomes for
patients living with serious illness. For this reason, national guidelines recommend that palliative care is
provided as part of standard serious illness care, and most hospitals in the U.S. have invested in specialist
palliative care programs. Yet, it has become clear that relying on clinicians to consistently recognize unmet
palliative care needs across different types of patients is impractical, and an important source of current
inefficiencies and inequities in hospital palliative care delivery, and systematic changes are needed. For this
reason, some hospitals have implemented screening criteria, or “triggers” in the electronic health record (EHR)
to facilitate more reliable and equitable patient identification; however, current diagnostic- and prognostic-
based criteria are nonspecific for unmet palliative care needs and exclude many patients with similar or greater
needs. Automating palliative care needs-based triggers surmounts these limitations, but evidence of their real-
world effectiveness to improve patient outcomes is needed. Further, it is not clear that a palliative care needs
trigger alone – which merely provides clinicians information – will be sufficient to meaningfully change clinician
behavior with regard to palliative care delivery. Thus, we hypothesize that a palliative care needs trigger in the
EHR will improve both patient-centered outcomes and the equity of palliative care delivery compared with
usual care, and that combining this trigger with an effective behavioral intervention (a default palliative care
consult order) will improve these outcomes further compared with the trigger alone. We will conduct a hybrid
type 1 pragmatic, cluster-randomized trial among more than 64,000 patients across 9 diverse hospitals to
study the effectiveness of these interventions on hospital-free days and numerous other patient-centered and
clinical outcomes, and the equity of palliative care consultation among different patient subgroups. During the
trial, we will conduct an embedded mixed-methods study to quantitively assess each intervention's reach,
adoption, implementation, and maintenance, and to qualitatively identify contextual factors and barriers to
enhance the interpretation of the trial findings and translation to other hospital settings. Our trial design has
several methodologic innovations, including a design that supports two randomized questions, a pre-planned
Bayesian interpretation, and newer effect modification methods. By providing high-quality, comparative
evidence of the real-world effectiveness, equity, and implementation of two scalable approaches to improve
hospital palliative c...

## Key facts

- **NIH application ID:** 10880905
- **Project number:** 1R01AG082874-01A1
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Katherine Rinaldi Courtright
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $690,884
- **Award type:** 1
- **Project period:** 2024-04-15 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10880905

## Citation

> US National Institutes of Health, RePORTER application 10880905, Improving the delivery and equity of inpatient palliative care: a hybrid type I pragmatic cluster trial (1R01AG082874-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10880905. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*
