# RISK FACTORS FOR CVD IN WOMEN

> **NIH NIH R01** · TULANE UNIVERSITY OF LOUISIANA · 2024 · $767,670

## Abstract

Abstract
Circulating proteomic profiles are strongly influenced by diet and may act as important molecular
transducers of the diet’s effects on coronary heart disease (CHD). Dietary quality and
circadian/temporal eating habits have been consistently related to CHD. However, how these factors
may affect CHD progression mechanistically remains poorly defined. Recent studies indicate that diet is
among the leading factors determining personalized and diet-specific differences in the proteome and
proteotypes defined by specific combinations of proteomic profiles. The overarching goal of this
proposal is to perform proteome-wide study of the dynamic interrelationships between diet (quality and
circadian/temporal eating patterns), circulating proteomic profiles, and CHD risk. Using an exceptionally
cost-efficient design that leverages existing resources from six large prospective cohorts: the Nurses’
Health Study (NHS), NHS2, the POUNDS LOST trial, Jackson Heart Study (JHS), Coronary Artery Risk
Development in Young Adults (CARDIA) Study, and UK Biobank, we propose to identify the
proteotypes for the dietary quality and circadian/temporal eating patterns measured by ‘gold standard’
and objective nutrition assessment methods (Aim 1). We will examine the associations of circulating
proteomic profiles (dietary factors and circadian/temporal eating patterns-related proteotypes, and
proteome-wide profiles) and their dynamic changes over 10 years with incidence of CHD (Aim 2). We
will also assess whether non-protein vascular risk factors for CHD mediate the proteome-CHD relation
(Aim 3). In addition, we will perform multi-omics analysis on the proteome-metabolome associations
with CHD (Aim 4). This renewal application is built upon an exceptional resource for understanding
CHD risk factors in women and has been continuously funded for 38 years (resulting in >410
publications and contributing to the training of >200 early-career investigators). The findings of our
proposed project are expected to lead to identification of new determinants of CHD at the molecular
level, offer novel insight into the mechanistic pathways, and advance the development of new
preventive and therapeutic strategies.

## Key facts

- **NIH application ID:** 10881076
- **Project number:** 2R01HL034594-36A1
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **Principal Investigator:** JoAnn Elisabeth Manson
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $767,670
- **Award type:** 2
- **Project period:** 1984-12-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10881076

## Citation

> US National Institutes of Health, RePORTER application 10881076, RISK FACTORS FOR CVD IN WOMEN (2R01HL034594-36A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10881076. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*