# Bioinformatics Core

> **NIH NIH U54** · WASHINGTON UNIVERSITY · 2024 · $179,247

## Abstract

BIOINFORMATICS CORE: SUMMARY
The Bioinformatics Core will support the WU-PDTC Research Projects and Cores over the spectrum of their
computational biology needs. The research program we propose involves many facets of algorithms,
computation, and information management, which require formalized bioinformatics support to effectively
translate results into recommendations for human clinical trials. The Bioinformatics Core will provide both the
infrastructure to house the experimental data and the interpretive tools and personnel to analyze these data.
These responsibilities fall into 3 basic categories. This will enable scaling the PDX-based approach into a
significant resource for the cancer research community in three important ways: (1) provide uniform, high-quality,
proteogenomic characterization for all WU-PDTC PDX tumor models for curation into the public domain, (2)
provide therapeutic response data on PDX models (e.g., breast, colon, pancreatic, and lung) including correlation
with molecular characterization and phenotypic response that may be applied to other cancer types with similar
characteristics, and (3) provide informatic and biostatistical tools to support evidence-based selection of
promising agents for subsequent clinical trials based on known molecular and clinical data. We will organize all
of this information, as well as all PDX-associated metadata (e.g. molecular and histopathologic data for both the
patient and PDX tumors, passages, and therapeutic experimental data, etc.), time series metrics representing
treatment responses, etc. in an extension of our WU-PDXdb relational tracking database developed in the prior
funding period. This will support both our local analysis and submission obligations and the information
integration with other PDTCs and PTCCCs. These informatic and statistical tools will be integrated across the
PDXNet to provide a valuable and lasting resource for future clinical and pre-clinical trial designs and possible
repurposing of drugs across cancer types.

## Key facts

- **NIH application ID:** 10881786
- **Project number:** 5U54CA224083-06
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Li Ding
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $179,247
- **Award type:** 5
- **Project period:** 2017-09-30 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10881786

## Citation

> US National Institutes of Health, RePORTER application 10881786, Bioinformatics Core (5U54CA224083-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10881786. Licensed CC0.

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