# Core B:  Biostatistics/Bioinfomatics Core

> **NIH NIH P01** · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $259,487

## Abstract

PROJECT SUMMARY 
The Program Project (P01) Biostatistics/Bioinformatics Core (BBC) will interact with all P01 investigators to 
develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. The Core 
will work closely with investigators to ensure that research questions lead to experiments with quantifiable goals 
and testable hypotheses. In addition, the Core will provide infrastructure and oversight for secure management 
of all study data (whether from publically available resources or generated as part of this P01), working closely 
with the Cores to facilitate accuracy and completeness of datasets for all projects and investigators. This will be 
accomplished through the following aims: 1) To support all P01 investigators in the study design, conduct, 
analysis, and reporting of results from all studies and 2) To provide secure and accessible database systems to 
facilitate reliable and reproducible analysis of results from the experiments conducted by all P01 investigators. 
The BBC serves as a centralized resource for all investigators involved in the P01, including all Projects and 
other Cores. The Core will assist investigators with all facets of study design, analysis, and interpretation, 
including appropriately powering experimental studies for sex differences. Established and innovative analytic 
methods are available to promote scientific discovery. Core personnel will interact with P01 investigators in all 
stages of research, from the formulation of the research questions, through experimental design, data 
management, data analysis (including outcomes analysis), interpretation, writing scientific manuscripts, to 
dissemination of results. The Core will also facilitate access to large datasets, whether from publically available 
resources (TCGA and other publically available -omic data) or generated as part of this P01 through bulk and 
single-cell sequencing in order to validate sex-specific molecular signatures and features identified in this P01. 
The Core will assist all investigators with development, management and reliability of their project data and will 
also integrate information across databases, such as incorporating clinical and experimental data with animal 
and biospecimen data as provided by the Experimental Models Core. The Core will provide a natural foundation 
for cross-pollination among the Projects and Cores. The BBC is integral to all components of the P01. We will 
be performing data management, statistical/bioinformatics consultation and interpretation of results as well as 
assisting with manuscripts/grants, throughout the entire grant period. Regular communication with the 
Administrative Core will be maintained in order to ensure tracking and management of all Projects and Cores. 
The BBC will work closely with the Experimental Models Core to assist with inventory of and tracking of use of 
specimens (animal and human) and merging of clinical and experimental in...

## Key facts

- **NIH application ID:** 10881805
- **Project number:** 5P01CA245705-05
- **Recipient organization:** CLEVELAND CLINIC LERNER COM-CWRU
- **Principal Investigator:** Jingqin Luo
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $259,487
- **Award type:** 5
- **Project period:** 2020-09-14 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10881805

## Citation

> US National Institutes of Health, RePORTER application 10881805, Core B:  Biostatistics/Bioinfomatics Core (5P01CA245705-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10881805. Licensed CC0.

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