# Center for comprehensive proteogenomic data analysis

> **NIH NIH U24** · BROAD INSTITUTE, INC. · 2024 · $751,571

## Abstract

Project Summary
Proteogenomics involves the integrative multi-omic analysis of genomic, transcriptomic, proteomic and post-
translational modification data produced by next-generation sequencing and mass spectrometry-based
proteomics. Several publications by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and others
have highlighted the impact of proteogenomics in enabling deeper insight into the biology of cancer and
identification of potential drug targets. Integrative analysis of multi-omic data requires the deployment of
complex algorithms and data processing techniques, which are generally inaccessible to scientists without a
background in bioinformatics and computational biology.
Our proposed center for comprehensive proteogenomic data analysis will encapsulate a comprehensive
set of analysis methods in a platform that will be (i) simple to use (ii) flexible (iii) automated, facilitating the
routine application to all CPTAC proteogenomic datasets as they become available, and (iv) able to
incorporate new methods with minimal effort. We will leverage PANOPLY--a cloud-based platform for
automated and reproducible proteogenomic data analysis--as the foundation, with specific, carefully chosen
algorithms targeted for addition to provide an expansive set of analysis capabilities that can be easily
harnessed to provide a rapid and extensive baseline analysis for proteogenomic studies, leading to many
disease specific hypotheses that can be explored further using additional computational and wet-lab
experiments.
Our collection of tools, algorithms and interactive reports will enable unprecedented, automated and integrative
systems-biology level analyses of proteome, post-translational modification and metabolomic data combined
with genomic data for individual disease cohorts and pan-cancer analysis across cohorts, leading to deeper
understanding of cancer biology and enabling identification of therapeutic targets and disease/prognostic
biomarkers.

## Key facts

- **NIH application ID:** 10883790
- **Project number:** 5U24CA271075-03
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** GAD A GETZ
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $751,571
- **Award type:** 5
- **Project period:** 2022-06-15 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10883790

## Citation

> US National Institutes of Health, RePORTER application 10883790, Center for comprehensive proteogenomic data analysis (5U24CA271075-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10883790. Licensed CC0.

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