# Cooperative Human Tissue Network

> **NIH NIH UM1** · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $829,244

## Abstract

PROJECT SUMMARY / ABSTRACT
The Cooperative Human Tissue Network (CHTN) was established as a mechanism to provide the scientific
community with high-quality human biospecimens for research. The CHTN allows investigators to access the
biospecimens they need to perform cutting-edge research, including basic and early translational cancer
research, and laboratory assay development.
As one of six CHTN Divisions, the Pediatric Division of the CHTN (pCHTN) will receive, process, and distribute
scientifically relevant biospecimens collected from children, adolescents, and young adults. These
biospecimens can include malignant, benign, disease-involved, and uninvolved biospecimens. The pCHTN
seeks to directly promote and support cutting-edge research in the diagnosis, biologic behavior, and treatment
of acute and chronic diseases including cancer by pursuing the following specific aims:
 1. To leverage the relationship with the Children’s Oncology Group , in addition to Nationwide Children’s
 Hospital Department of Pathology and Laboratory Medicine to procure a wide range of well-annotated
 biospecimens from a variety of both cancerous and non-cancerous conditions, including biospecimens
 from rare tumor types.
 2. To support cutting-edge research by distributing high-quality biospecimens to approved investigators.
 3. To maximize limited biospecimen resources and provide economies of scale by performing additional
 processing of biospecimens (e.g., nucleic acid extraction, tissue microarray creation, digital images of
 stained tissue slides, etc.)
 4. To maintain a reliable and robust Quality Management Program that monitors all aspects of
 biospecimen collection, processing, storage, and distribution in an effort to continuously evaluate and
 improve our operational capabilities, assess best practices, ensure investigator satisfaction, and protect
 the privacy and confidentiality of those individuals from whom the biospecimens and data were
obtained.
 5. To actively contribute to the CHTN by participation and collaboration in Network interactions,
 particularly in fulfilling highly customized or non-standard requests, participating in collaborative
 Network activities, and coordinating or developing new strategies to ensure that the CHTN remains
 responsive to the needs of the scientific community.

## Key facts

- **NIH application ID:** 10884729
- **Project number:** 2UM1CA239754-06
- **Recipient organization:** RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- **Principal Investigator:** NILSA DEL CARMEN RAMIREZ MILAN
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $829,244
- **Award type:** 2
- **Project period:** 2019-04-16 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10884729

## Citation

> US National Institutes of Health, RePORTER application 10884729, Cooperative Human Tissue Network (2UM1CA239754-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10884729. Licensed CC0.

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