# The CASCADE CLIMB: Cervical cancer prevention in women Living with HIV research Mobilization Base

> **NIH NIH UG1** · UNIVERSITY OF WASHINGTON · 2024 · $674,985

## Abstract

The overall goal of The CASCADE CLIMB (Cervical cancer prevention in women Living with HIV (WLWH)
research Mobilization Base) is to generate critical evidence to inform optimization, implementation, and scale-
up of effective cervical cancer prevention interventions for WLWH. Functioning as a scientific hub of the
CASCADE Network, CLIMB will drive the network's scientific agenda through skilled and innovative scientific
and statistical leadership, rigorous and robust operational oversight, and training and capacity-building
opportunities to facilitate research, implementation, and scale-up of cervical cancer prevention interventions in
intended-use settings. Our highly capable team of investigators has complimentary and integrated
multidisciplinary research and clinical expertise in HPV/cervical cancer prevention and control, gynecologic
oncology, women's health, and HIV/AIDS; methodological expertise in epidemiology, statistics, and
implementation science; and a strong record of leading clinical trials and studies across the continuum of
effectiveness to implementation research in both the US and in low- and middle-income countries (LMICs). The
specific aims are to: 1) Develop and conduct rigorous pragmatic, multi-site clinical trials that address unmet
needs in cervical cancer prevention for WLWH, and 2) Nurture emerging investigators in resource-limited
settings by offering mentorship, capacity-building opportunities and training in the skills and disciplines needed
to lead future research in cervical cancer prevention. We will develop trial concepts and protocols and lead
implementation, operational oversight, statistical analysis, and manuscript preparation for three trials. We
propose pragmatic trials to evaluate important clinical effectiveness and implementation outcomes in the US
and in LMICs, with the following aims: 1) Compare strategies for offering HPV self-sampling vs. local standard
of care screening approaches on rates of screening and precancer detection; 2) Compare molecular triage
(e.g., p16/ki-67 dual stain, methylation) vs. immediate ablation after an HPV-positive result on follow-up rates
of HPV/precancer detection; 3) Compare a task shifting strategy to nurses with electronic quality assurance for
same day cervical cancer screening and treatment vs. usual care procedures that require referral for follow-up
on rates of screening and treatment; and 4) Compare thermal ablation vs. LEEP for treating precancers in
WLWH with type 2 transformation zones on rates of post-treatment HPV detection/precancer recurrence. We
will leverage the University of Washington Department of Global Health's Treatment, Research, and Expert
Education and E-Learning Programs to deliver training and capacity-building activities to CASCADE Clinical
Sites, including synchronous online courses in research fundamentals, virtual and on-site trainings to build
research capacity, and on-site clinical training in cervical cancer prevention. We will promote dev...

## Key facts

- **NIH application ID:** 10885125
- **Project number:** 5UG1CA275402-03
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Elizabeth Renata Brown
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $674,985
- **Award type:** 5
- **Project period:** 2022-09-20 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10885125

## Citation

> US National Institutes of Health, RePORTER application 10885125, The CASCADE CLIMB: Cervical cancer prevention in women Living with HIV research Mobilization Base (5UG1CA275402-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10885125. Licensed CC0.

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