# RESPIRATORY CONTROL AND EMOTION REGULATION

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $382,200

## Abstract

Over the past few decades, research involving the neural control of breathing has centered on how the
breathing rhythm is generated and how sensory systems detect internal and external changes to modulate the
breathing pattern. While we have learned that the regulatory breathing rhythm originates in the medulla, we
know little about the neural circuits by which breathing affects emotional state. The positive effects of controlled
breathing on emotional state have been observed across many contexts and in the clinic. Using objective
behavioral, physiological, and neuroanatomical parameters, we propose: i) to fully determine the neural
pathways in mice from the preBötzinger Complex, the key site generating inspiratory rhythm in the medulla, to
supramedullary regions, in particular to the locus coeruleus and its ascending projections, that effect and/or
affect emotional state, and; ii) to establish the role of these projections from the preBötzinger Complex in
mediating the effects of breathing on anxiety, fear and panic in mice. The proposed research has the potential
to lead to more effective methods for treating debilitating negative emotional states

## Key facts

- **NIH application ID:** 10885132
- **Project number:** 5R01AT012412-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** JACK L FELDMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $382,200
- **Award type:** 5
- **Project period:** 2022-09-19 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10885132

## Citation

> US National Institutes of Health, RePORTER application 10885132, RESPIRATORY CONTROL AND EMOTION REGULATION (5R01AT012412-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10885132. Licensed CC0.

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