PROJECT SUMMARY The goal of the Rodent Phenotyping Core (RPC) is to increase the utility of mice and rats as model organisms for vision research at The University of Iowa. The availability of a centralized core for phenotyping will allow investigators to focus their resources on the science and discoveries underlying vision research, rather than on training each lab’s personnel to perform phenotyping. Such core-based services will yield more consistent and reproducible phenotyping measures and in turn maximize the power of NEI-funded investigators to make new discoveries. The RPC will have the capability to perform detailed phenotyping of the anterior segment (slit- lamp examination and photography, SD-OCT, gonioscopy, fluorescein angiography, and intraocular pressure recording) and the posterior segment (fundus examination/photography, electroretinogram, pupil light reflex, behavioral measurements of vision, acute suppression of activity by light, and testing of optokinetic response).