# Reversibility of brain glucose kinetics in type 2 diabetic subjects

> **NIH NIH K23** · YALE UNIVERSITY · 2024 · $194,724

## Abstract

Project summary/abstract
 The prevalence of type 2 diabetes mellitus continues to rise worldwide and despite different treatment
options, many patients fail to achieve glycemic target, which leads to increased morbidity and mortality.
Chronic exposure to hyperglycemia has been shown in both animal and human studies to decrease glucose
transport into the brain, presumably through down-regulation of GLUT1 at the blood brain barrier, which has
been postulated to be a protective adaptation of the central nervous system against the harmful consequences
of hyperglycemia. However, GLUT1 down regulation may lead to reduced brain glucose metabolism leading to
neuronal damage, neurodegeneration and cognitive decline. Whether these changes in cerebral glucose
transport seen in patients with poorly controlled diabetes can be reversed is unknown. The main goal of this
study is to determine whether improvement of glucose control in poorly controlled T2DM patient will restore
brain glucose transport kinetics and rigorously assess which factors (i.e. duration DM and glycemic control)
contribute to the observed improvements by using classic metabolic studies as well as state-of-the-art brain
nuclear magnetic resonance spectroscopy (MRS) techniques. The findings obtained from this study will help
elucidate if intensive diabetes therapy may be associated with reduced brain dysfunction from hyperglycemia.

## Key facts

- **NIH application ID:** 10885958
- **Project number:** 5K23DK132517-02
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Elizabeth Sanchez Rangel
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $194,724
- **Award type:** 5
- **Project period:** 2023-07-15 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10885958

## Citation

> US National Institutes of Health, RePORTER application 10885958, Reversibility of brain glucose kinetics in type 2 diabetic subjects (5K23DK132517-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10885958. Licensed CC0.

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