# Trivalent Live Attenuated Vaccines for Bacterial Acute Otitis Media

> **NIH NIH R21** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $273,000

## Abstract

Summary
Clinically, AOM is the leading reason for pediatrician visits and antibiotic usage by children. The
predominant causative agents of AOM are Streptococcus pneumoniae, Haemophilus
influenzae, and Moraxella catarrhalis. While currently licensed capsule-based vaccines have
dramatically lowered in the incidence of invasive pneumococcal disease, the incidence of
mucosal infections such as AOM has remained relatively unchanged. Likewise, non-typeable H.
influenzae currently predominates the AOM landscape following introduction of the Hib vaccine.
Additionally complicating matters is the potential concern that a vaccine targeting an individual
otopathogen may not reduce overall incidence of AOM due to the non-targeted pathogens
becoming more predominant following the removal of an individual pathogen. We have
engineered a safe, effective, and highly manipulatable platform for delivering protein epitopes to
the mucosal surface to target multiple otopathogens simultaneously while engendering
protective immunity at the mucosal surface. Leveraging a combinatorial approach for eliminating
multiple AOM pathogen simultaneously using a live vaccine platform to maximize mucosal
antibody responses represents a novel strategy for reducing the burden of AOM in children.

## Key facts

- **NIH application ID:** 10887120
- **Project number:** 1R21AI178085-01A1
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Jason W. Rosch
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $273,000
- **Award type:** 1
- **Project period:** 2024-02-01 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10887120

## Citation

> US National Institutes of Health, RePORTER application 10887120, Trivalent Live Attenuated Vaccines for Bacterial Acute Otitis Media (1R21AI178085-01A1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10887120. Licensed CC0.

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