# Proteomics

> **NIH NIH P30** · STANFORD UNIVERSITY · 2024 · $60,917

## Abstract

PROJECT SUMMARY
The Proteomics Shared Resource (P-SR) is focused on fostering high-impact cancer-relevant research by
providing SCI members with access to state-of-the-art, user-friendly mass spectrometry-based resources and
expertise. The P-SR operates 15 mass spectrometer systems that serve ~60 SCI researchers annually.
Research support goals are accomplished via the following technical capabilities (1) full-service research
partnership from experiment design through sample preparation and mass spectrometric analysis to data
analysis; (2) broad-spectrum proteomic support from pilot discovery through complex quantitative assays; (3)
customizable quantitative small molecule and clinical scale proteomic assays, taking advantage of modern
advances in multiplexing and targeted techniques; (4) intact protein characterization, including antibodies and
antibody-drug conjugates; (5) open access walk-up instrumentation and hands-on experience; and (6) online
and in-person education, training, and network-building opportunities. These technical capabilities are
foundational to numerous scientific areas, such as (1) discovering relevant molecular targets in cancer; (2)
providing accurate, orthogonal means of validating research findings from genomic and transcriptomic analyses
at the protein level; (3) supporting cancer drug discovery efforts with pharmacokinetics and metabolism analytics;
and (4) investigating biological pathways and signaling mechanisms relevant to cancer, both for target and
biomarker discovery.
Since the last review, the P-SR has continued to acquire new high-end instrumentation, including a Thermo
Scientific Q Exactive HF-X and a Waters Xevo TQ-XS. Members of all programs use the P-SR, with the heaviest
use coming from the Cancer Biology and Cancer Stem Cells and Cancer Therapeutics programs. In 2020, 41%
of users were SCI investigators. The P-SR contributed to 10 cancer-focused publications (5 high-impact). The
annual budget of the P-SR is $1,547,560, yet the CCSG request is $70,495. Accordingly, the P-SR leverages
extensive institutional support and seeks only 5% from CCSG funds.

## Key facts

- **NIH application ID:** 10887449
- **Project number:** 5P30CA124435-16
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Allis Soe-Lang Chien
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $60,917
- **Award type:** 5
- **Project period:** 2007-06-04 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10887449

## Citation

> US National Institutes of Health, RePORTER application 10887449, Proteomics (5P30CA124435-16). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10887449. Licensed CC0.

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