# Emory Alzheimer's Disease Research Center

> **NIH NIH P30** · EMORY UNIVERSITY · 2024 · $337,662

## Abstract

SUMMARY/ABSTRACT: BIOMARKER CORE 
Alzheimer’s disease (AD) is a chronic disease that progresses through a lengthy asymptomatic period 
before entering a period of mild cognitive impairment (MCI) and dementia. Using current biomarker 
tools, we can determine with a fair degree of confidence whether or not AD-related pathology is present 
in a living individual. However, there remain major limitations in the capabilities of AD biomarkers, and 
there is a critical need for new biomarkers to overcome remaining barriers. The proposed Biomarker 
Core will support research activities in the Emory ADRC by pursuing three Specific Aims: 1) Perform 
and analyze standardized genetic profiling and explore promising candidates; 2) Perform and analyze 
standardized CSF AD biomarker assays and explore promising candidates; 3) Perform and analyze 
standard brain imaging and evaluate promising additional sequences. The proposed Biomarker Core 
will provide a number of important enhancements to the research environment. Longitudinal collection 
of common datasets, including clinical information, CSF AD biomarkers, core genetic information, and 
standard brain MRI sequences, will provide foundations upon which new AD biomarkers can be tested, 
evaluated, and confirmed. Exploratory research in each of these areas should provide significant 
advances in CSF proteomics, new MR sequences, and genomic data. Lastly, the current proposal 
engages a group of talented investigators who will bring their expertise to the ADRC and the larger 
research community. Each of these elements advance the overall goals of the ADRC and will provide a 
wealth of data for new trainees.

## Key facts

- **NIH application ID:** 10887576
- **Project number:** 5P30AG066511-05
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Nicholas Thomas Seyfried
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $337,662
- **Award type:** 5
- **Project period:** 2020-07-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10887576

## Citation

> US National Institutes of Health, RePORTER application 10887576, Emory Alzheimer's Disease Research Center (5P30AG066511-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10887576. Licensed CC0.

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