# Regulation of IgG Sialylation

> **NIH NIH F31** · CASE WESTERN RESERVE UNIVERSITY · 2024 · $36,694

## Abstract

Project Abstract:
 The association between decreased plasma IgG sialylation and a variety of inflammatory diseases has
been known for decades. The downstream effects of changes in IgG sialylation have been studied in depth, and
it is now believed that decreases in sialylation increase the affinity of IgG for activating Fc receptors, thereby
driving immune activation throughout the body. Although the downstream effects of dysregulated IgG sialylation
have been well documented, the regulatory mechanisms controlling IgG sialylation remain unknown. If these
mechanisms are elucidated, they may serve as novel therapeutic targets to manipulate IgG function to either
enhance or suppress IgG-based inflammation, depending on the circumstances. Previous research has
suggested that, unlike many other glycoproteins, IgG is not sialylated efficiently during the secretory process,
pointing to a B cell-extrinsic mechanism in which IgG sialylation is dynamically regulated following its release
into the bloodstream. Therefore, the goals of the proposed studies are (1) to identify key regulatory mechanisms
underlying IgG sialylation and (2) to elucidate how inflammatory signals are translated into changes in the IgG
glycan. The success of this study will be characterized by revealing a novel and dynamic mechanism regulating
IgG function through regulated changes in glycan sialylation, while providing cutting-edge scientific and
professional training that blends both glycobiology and immunology to facilitate a career trajectory focused upon
leadership in IgG-based therapies and translational science.

## Key facts

- **NIH application ID:** 10888183
- **Project number:** 5F31AI178953-02
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Leandre Glendenning
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $36,694
- **Award type:** 5
- **Project period:** 2023-08-01 → 2025-05-16

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10888183

## Citation

> US National Institutes of Health, RePORTER application 10888183, Regulation of IgG Sialylation (5F31AI178953-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10888183. Licensed CC0.

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