Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The overarching goal of the Indiana Core Center for Clinical Research (ICCCR) – the Indiana Center for Musculoskeletal Health Clinical Research Center (ICMH-CRC) is to provide the needed training and resources to enhance clinical research in musculoskeletal disorders to improve musculoskeletal health across a broad range of diseases and populations. In Aim 1 we will deploy the Administrative Core to facilitate cross disciplinary clinical research by connecting MSK researchers with investigators studying chronic disease, enhance work with the community to educate, inform, recruit and assess disadvantaged and minoritized populations, provide pilot funding, and train the next generation of musculoskeletal researchers. We will innovate through increased community engagement with racial and ethnically diverse populations to encourage participation in MSK research. In Aim 2, we will integrate and harmonize big data from multiple data sources in the Musculoskeletal Informatics Methodology (MIM) Core. We will develop a facile, secure and innovative MSK Data Mart that integrates and harmonizes 1) The state-wide “traditional” electronic health record (EHR), 2) Measures of social and structural determinants of health based on geocoding, 3) The prospective collection of data from the FIT Core, and 4) genomics and sample availability from the MSK Biobank. The Data Mart will expand our core linkage and maximize MSK assessment based on the computable (computer data derived) phenotypes developed and refined during our first P30. In Aim 3, we will foster growth of the Musculoskeletal Function, Imaging, and Tissue (FIT) Resource Core to provide standardized assessments of musculoskeletal health and expand the availability of biospecimens to facilitate exploration of musculoskeletal health and disease. We will innovate our resource Core (FIT Core) by taking the Core “on the road’ to the community health centers and organizations, diversifying our tested population to develop race and ethnicity specific Z scores. We will also perform whole exome sequencing on DNA collected from the participants to expand the utility of the MSK functional (physical function), morphologic (imaging), and computable (electronic health record) phenotypes by linking with genomic data. These goals will serve to promote and advance clinical research in MSK disorders leading to prevention, diagnosis, treatment and cure for ALL individuals.