# Admin Core

> **NIH NIH U2C** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $255,597

## Abstract

ADMINISTRATIVE CORE ABSTRACT
The discovery-to-translation pipeline of the BU-UCLA Lung Cancer Biomarker Characterization Center is
enabled by a multi-disciplinary team of investigators with diverse expertise. This Center is comprised of a
Biomarker Development Laboratory and a Biomarker Reference Laboratory that each have three teams working
on different approaches to the early detection of lung cancer utilizing biospecimens and clinical data being
collected in several large clinical studies. These teams are distributed across multiple institutions including
universities, academic medical centers, and two private companies. The operational complexity of the BU-UCLA
Lung Cancer BCC will be effectively managed by the BCC’s Administrative Core. The Administrative Core will
strengthen linkages within the Biomarker Discovery Lab and Biomarker Reference Lab components and help
those investigators deliver on their respective milestones. It will further create strong linkages between the
Biomarker Discovery Lab, the Biomarker Reference Lab, and the clinical studies via an Administrative Core-
facilitated BU-UCLA BCC Steering Committee whose members will be the BCC Principal Investigators and co-
Investigators. Sub committees of the Steering Committee will have responsibility for important center-wide
activities such as biomarker qualification, review of clinical enrollment and clinical data, adjudication of
diagnoses, selection of cases and controls, biospecimen QC, early-stage investigator training, and the
dissemination of the Center’s work. The Administrative Core will also facilitate a BU-UCLA BCC Executive
Committee made up of the MPI team that will provide oversight of the entire program and have final responsibility
for Center decision-making as well as development and implementation of all policies, procedures, and
processes. The Administrative Core’s Internal and External Advisory Boards will provide regular external
evaluation of the BCC’s progress while also helping maintain the Center’s focus on addressing the most
important clinical problems using the most innovative approaches. Finally, the Administrative Core will serve as
the interface between the BCC, EDRN leadership and the NCI to ensure that the BCC conforms with the agreed
practices and principles of the EDRN, ensure bidirectional exchange of findings and insights with other EDRN
Centers, coordinate with other EDRN Centers to support validation of EDRN-developed biomarkers, and
participate in collaborative projects.

## Key facts

- **NIH application ID:** 10888982
- **Project number:** 5U2CCA271898-03
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** Marc Elliott Lenburg
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $255,597
- **Award type:** 5
- **Project period:** 2022-09-01 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10888982

## Citation

> US National Institutes of Health, RePORTER application 10888982, Admin Core (5U2CCA271898-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10888982. Licensed CC0.

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