# Biomarker Reference Lab

> **NIH NIH U2C** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $160,252

## Abstract

BIOMARKER REFERENCE LAB ABSTRACT
The Biomarker Reference Laboratory (BRL) of the BU-UCLA Lung Cancer Biomarker Characterization Center
(BCC) will work to ensure that the biomarkers developed and evaluated by our Biomarker Discovery Lab (BDL)
can be robustly measured in the clinical setting using material collected and analyzed using CLIA-lab protocols.
Like the BDL, the BRL will be organized into analyte specific teams. Reference Lab studies will be performed in
collaboration with our industrial partners for the nasal gene expression, circulating tumor cell (CTC) and
peripheral blood mononuclear cells (PBMC) biomarkers, and at the UCLA Imaging Biomarker Reference
Laboratory (IBRL) for the imaging biomarkers. Each entity within the BRL has had a long-standing collaboration
with our BDL teams. The BRL will also assess biospecimen, imaging and molecular data quality and convey that
information to the collecting sites and the BDL to ensure that all sites are collecting high quality specimens and
generating high quality data. The goals of these collaborative efforts are to rigorously assess the validity of
candidate biomarkers for the early detection of lung cancer that are identified in the BDL, and develop either
refined algorithms that currently exist in our commercial partners’ laboratories or novel CLIA assays that can
emerge in the commercial marketplace for clinical use. The major goals are that these tests have high
reproducibility, accuracy, precision, sensitivity, and specificity.

## Key facts

- **NIH application ID:** 10888985
- **Project number:** 5U2CCA271898-03
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** MICHAEL J PALAZZOLO
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $160,252
- **Award type:** 5
- **Project period:** 2022-09-01 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10888985

## Citation

> US National Institutes of Health, RePORTER application 10888985, Biomarker Reference Lab (5U2CCA271898-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10888985. Licensed CC0.

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